| Final | time | L | seed | ______ | | 1. South Africa | 4:14.00 | 4 | 4:04.97 | | | Karin Prinsloo, Suzaan Van Biljon, Mandy Loots, Natasha De Vos | | 2. Zimbabwe | 4:24.01 | 5 | 4:09.98 | | | Kirsten Lapham, Samantha Welch, Kirsty Coventry, Nicole Horn | | 3. Algeria | 4:29.29 | 3 | 4:25.00 | | | Amel Melih, Melia Bekhouche, Sarah Abdelrahmane, Fella Benaceur | | 4. Mozambique | 4:34.98 | 6 | 4:29.30 | | | Jessica Cossa, Mariam Corsini, Gessica Stagno, Jessica vieira | | 5. Kenya | 4:50.01 | 7 | 4:56.78 | | | Talisa Lanoe, Sonia Cege, Sylvia Brunlehner, Soraya Oruya | | 6. Nigeria | 4:52.52 | 2 | 4:56.30 | | | Faith Erododion, Doutimi Gagbe, Ifiezibe Gagbe, Racheal Tonjor |
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| Record - 2007 | | South Africa 4:10.90 |
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