| Final A | Team | time | -)time | L | React. | 100m | 200m | 300m | | 1. Julia Elizabeth Smit | USA | 4:46.15 | | 4 | 0.76s | 5. | 1:06.60 | 3. | 2:18.46 | 2. | 3:40.76 | | 2. Joanna Maranhao | BRA | 4:46.33 | 0.18s | 3 | | 1. | 1:03.84 | 2. | 2:17.98 | 3. | 3:42.60 | | 3. Allysa Mary Vavra | USA | 4:48.05 | 1.90s | 5 | | 2. | 1:06.06 | 1. | 2:17.54 | 1. | 3:40.55 | | 4. Hanna Pierse | CAN | 4:52.95 | 6.80s | 1 | | 8. | 1:08.44 | 7. | 2:23.68 | 5. | 3:44.46 | | 5. Georgina Bardach | ARG | 4:53.81 | 7.66s | 6 | | 6. | 1:07.12 | 6. | 2:22.44 | 4. | 3:44.33 | | 6. Susana Escobar | MEX | 4:54.49 | 8.34s | 7 | | 3. | 1:06.50 | 5. | 2:21.56 | 7. | 3:49.87 | | 7. Karyn Jewell | CAN | 4:57.65 | 11.50s | 2 | | 4. | 1:06.54 | 4. | 2:21.27 | 6. | 3:48.93 | | 8. Samantha Arevalo | ECU | 4:58.27 | 12.12s | 8 | 0.83s | 7. | 1:08.24 | 8. | 2:25.09 | 8. | 3:52.91 |
| Final B | Team | time | -)time | L | React. | 100m | 200m | 300m | | 9. Julia Arino | ARG | 5:01.20 | | 4 | 0.57s | 5. | 1:08.91 | 1. | 2:25.42 | 1. | 3:52.55 | | 10.Montserrat Ortuno | MEX | 5:04.07 | 2.87s | 3 | | 1. | 1:05.44 | 3. | 2:27.11 | 2. | 3:54.49 | | 11.Eliana Barrios | VEN | 5:04.10 | 2.90s | 5 | | 2. | 1:06.43 | 2. | 2:25.96 | 3. | 3:56.57 | | 12.Larissa Cieslak | BRA | 5:12.83 | 11.63s | 6 | | 3. | 1:08.35 | 4. | 2:28.71 | 4. | 4:00.91 | | 13.Barbara Caraballo | PUR | 5:17.61 | 16.41s | 7 | 0.70s | 4. | 1:08.55 | 5. | 2:28.78 | 5. | 4:02.58 | | 14.Zara Bailey | JAM | 5:17.72 | 16.52s | 1 | 0.81s | 6. | 1:11.20 | 6. | 2:33.37 | 6. | 4:04.24 | | 15.Patricia Quevedo | PER | 5:20.50 | 19.30s | 2 | | 8. | 1:14.77 | 8. | 2:39.96 | 7. | 4:09.33 | | 16.Lani Cabrera | BAR | 5:22.06 | 20.86s | 8 | 0.83s | 7. | 1:12.72 | 7. | 2:36.55 | 8. | 4:14.50 |
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| World record: | | Stephanie Rice (AUS) 4:29.45 | | Beijing (CHN) 10.08.2008 | | Pan American Games record: | | Joanne Malar () 4:38.46 | | Winnipeg (CAN) 02.08.1999 |
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| Qualification: | | Standard A: 5:19.0 | | Standard B: 5:28.6 |
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| Heats | Team | time | -)time | L | React. | 100m | 200m | 300m | Heat | | 1. Julia Elizabeth Smit | USA | 4:51.78 | | 4 | 0.74s | 1. | 1:05.22 | 1. | 2:17.84 | 1. | 3:42.13 | Heat 4. | | 2. Allysa Mary Vavra | USA | 4:53.76 | 1.98s | 4 | 0.73s | 1. | 1:04.86 | 1. | 2:16.40 | 1. | 3:42.66 | Heat 3. | | 3. Joanna Maranhao | BRA | 4:54.51 | 2.73s | 4 | | 1. | 1:04.51 | 1. | 2:20.20 | 1. | 3:46.39 | Heat 2. | | 4. Georgina Bardach | ARG | 4:57.58 | 5.80s | 5 | | 3. | 1:07.39 | 2. | 2:22.46 | 2. | 3:45.53 | Heat 3. | | 5. Karyn Jewell | CAN | 4:57.81 | 6.03s | 5 | | 2. | 1:06.55 | 2. | 2:21.56 | 2. | 3:49.39 | Heat 4. | | 6. Susana Escobar | MEX | 4:58.57 | 6.79s | 3 | | 3. | 1:06.67 | 3. | 2:22.54 | 3. | 3:52.11 | Heat 4. | | 7. Hanna Pierse | CAN | 4:59.76 | 7.98s | 5 | | 3. | 1:08.83 | 2. | 2:25.85 | 2. | 3:48.48 | Heat 2. | | 8. Samantha Arevalo | ECU | 5:02.29 | 10.51s | 3 | | 4. | 1:09.19 | 3. | 2:26.06 | 3. | 3:53.98 | Heat 3. | | 9. Julia Arino | ARG | 5:06.78 | 15.00s | 6 | | 5. | 1:09.67 | 5. | 2:27.48 | 5. | 3:57.25 | Heat 3. | | 10.Eliana Barrios | VEN | 5:07.70 | 15.92s | 2 | | 2. | 1:06.57 | 4. | 2:26.86 | 4. | 3:56.79 | Heat 3. | | 11.Montserrat Ortuno | MEX | 5:08.47 | 16.69s | 3 | | 2. | 1:05.79 | 3. | 2:27.72 | 3. | 3:57.53 | Heat 2. | | 12.Larissa Cieslak | BRA | 5:09.81 | 18.03s | 6 | | 4. | 1:07.61 | 4. | 2:27.11 | 4. | 3:58.98 | Heat 4. | | 13.Patricia Quevedo | PER | 5:13.30 | 21.52s | 7 | 0.87s | 8. | 1:13.11 | 7. | 2:36.14 | 5. | 4:02.39 | Heat 4. | | 14.Barbara Caraballo | PUR | 5:17.07 | 25.29s | 2 | | 6. | 1:08.86 | 6. | 2:29.59 | 6. | 4:03.17 | Heat 4. | | 15.Zara Bailey | JAM | 5:19.46 | 27.68s | 2 | 0.82s | 4. | 1:09.34 | 4. | 2:31.63 | 4. | 4:05.45 | Heat 2. | | 16.Lani Cabrera | BAR | 5:19.66 | 27.88s | 1 | | 6. | 1:10.56 | 6. | 2:34.51 | 5. | 4:12.06 | Heat 2. | | 17.Daniela Reyes | CHI | 5:20.05 | 28.27s | 5 | | 2. | 1:10.90 | 2. | 2:35.65 | 1. | 4:06.69 | Heat 1. | | 18.Laura Rodriguez | DOM | 5:22.28 | 30.50s | 3 | | 1. | 1:10.87 | 1. | 2:27.41 | 2. | 4:07.09 | Heat 1. | | 19.Daniella Van Den Berg | ARU | 5:24.75 | 32.97s | 8 | | 7. | 1:12.11 | 8. | 2:38.62 | 8. | 4:11.88 | Heat 4. | | 20.Ana Castellanos | HON | 5:26.80 | 35.02s | 7 | 0.71s | 6. | 1:09.75 | 6. | 2:32.41 | 6. | 4:07.25 | Heat 3. | | 21.Maria Alejandra Torres | PER | 5:27.30 | 35.52s | 7 | 0.77s | 5. | 1:10.01 | 5. | 2:33.49 | 6. | 4:13.74 | Heat 2. | | 22.Karen Vilorio | HON | 5:27.31 | 35.53s | 1 | | 5. | 1:08.55 | 5. | 2:29.17 | 7. | 4:08.20 | Heat 4. | | 23.Lara Maria Butler | CAY | 5:35.96 | 44.18s | 1 | | 7. | 1:13.35 | 7. | 2:36.28 | 7. | 4:17.81 | Heat 3. | | 24.Amara Gibbs | BAR | 5:38.27 | 46.49s | 4 | | 3. | 1:11.97 | 3. | 2:35.71 | 3. | 4:22.18 | Heat 1. | | -. Daniela Victoria | VEN | DNS | | 6 | | Heat 2. |
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