| Final | time | | L | | 1. Jereem Richards |  Trinidad Tobago | 45.00 | CR NR | 6 | | 2. Trevor Bassitt |  United States | 45.05 | PB | 4 | | 3. Carl Bengtström |  Sweden | 45.33 | NR | 5 | | 4. Benjamin Lobo Vedel |  Denmark | 45.67 | NR | 3 | | 5. Patrik Šorm |  Czechia | 46.81 | | 2 | | 6. Marqueze Washington | United States | 46.85 | | 1 |
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| Venue: Štark Arena, Cap.: 18,386. Final Sat 19.03.22 --:--. |
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| | | 2 Heats with 12 Athletes. First 3 from each Heat advanced to Final. |
| Ranking | time | | H | L | | 1. Carl Bengtström | Sweden | 45.92s | Q | 2 | 6 | | 2. Jereem Richards | Trinidad Tobago | 46.15s | Q | 1 | 4 | | 3. Trevor Bassitt | United States | 46.26s | Q | 2 | 4 | | 4. Benjamin Lobo Vedel | Denmark | 46.30s | Q | 1 | 3 | | 5. Marqueze Washington | United States | 46.36s | Q | 1 | 5 | | 6. Julien Watrin |  Belgium | 46.54s | | 1 | 6 | | 7. Patrik Šorm | Czechia | 46.55s | Q | 2 | 5 | | 8. Bruno Hortelano |  Spain | 46.76s | | 2 | 1 | | 9. Mikhail Litvin |  Kazakhstan | 46.89s | | 1 | 2 | | 10.Boško Kijanović |  Serbia | 46.97s | | 2 | 2 | | 11.Kajetan Duszyński |  Poland | 47.21s | | 1 | 1 | | -. Christopher Taylor |  Jamaica | DNFs | | 2 | 3 |
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| | | 5 Heats with 25 Athletes. First 2 from each Heat and Best 2 times advanced to Semi-Finals. |
| Ranking | time | | H | L | | 1. Julien Watrin | Belgium | 45.88s | Q, NR | 1 | 6 | | 2. Carl Bengtström | Sweden | 46.45s | Q | 5 | 6 | | 3. Trevor Bassitt | United States | 46.47s | Q | 1 | 5 | | 4. Christopher Taylor | Jamaica | 46.48s | Q | 5 | 4 | | 5. Bruno Hortelano | Spain | 46.49s | q | 5 | 5 | | 6. Patrik Šorm | Czechia | 46.49s | Q | 3 | 5 | | 7. Benjamin Lobo Vedel | Denmark | 46.58s | Q | 3 | 6 | | 8. Marqueze Washington | United States | 46.66s | Q | 4 | 5 | | 9. Jereem Richards | Trinidad Tobago | 46.69s | Q | 2 | 5 | | 10.Mikhail Litvin | Kazakhstan | 46.72s | Q | 2 | 4 | | 11.Kajetan Duszyński | Poland | 46.75s | q | 1 | 3 | | 12.Patrick Schneider |  Germany | 46.76s | | 3 | 4 | | 13.Tom Willems |  Australia | 46.77s | | 3 | 3 | | 14.Boško Kijanović | Serbia | 46.88s | Q | 4 | 4 | | 15.Zakithi Nene |  South Africa | 46.92s | | 2 | 3 | | 16.Håvard Bentdal Ingvaldsen |  Norway | 46.95s | | 5 | 3 | | 17.Isayah Boers |  Netherlands | 47.07s | | 1 | 4 | | 18.Pavel Maslák | Czechia | 47.31s | | 4 | 3 | | 19.Mazen Al-Yassin |  Saudi Arabia | 47.65s | | 1 | 2 | | 20.Manuel Guijarro | Spain | 47.74s | | 2 | 6 | | 21.Jovan Stojoski |  North Macedonia | 47.80s | | 4 | 2 | | 22.Pau Blasi |  Andorra | 49.82s | | 2 | 2 | | 23.Quentin Petit |  Comoros | 51.55s | SB | 3 | 2 | | 24.Malique Smith |  US Virgin Islands | 51.98s | SB | 5 | 2 | | -. Lucas Carvalho |  Brazil | DQ TR17.4.3 | 4 | 6 |
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