| Final | | dates | team 1 | leg 1 | leg 2 | team 2 | HT1 | HT2 | aggr. | | 27.11,13.12 | JE Tizi-Ouzou |  ALG | 4-0 | 1-0 | AS Vita Club |  ZAI | --- | --- | 5-0 | | Leg 1: Omnisport, Tizi-Ouzou. Leg 2: 20th May Stadium, Kinshasa |
| dates | team 1 | leg 1 | leg 2 | team 2 | HT1 | HT2 | aggr. | | --.--,--.-- | JE Tizi-Ouzou | ALG | wo | wo | Al-Ahly |  EGY | --- | --- | w/o | | --.--,--.-- | AS Vita Club | ZAI | 1-0 | 0-0 | AS Kaloum Star |  GUI | --- | --- | 1-0 |
Al-Ahli withdrew due to the political situation in Egypt after the assasination of Anwar Sadat.
| dates | team 1 | leg 1 | leg 2 | team 2 | HT1 | HT2 | aggr. | | --.--,--.-- | JE Tizi-Ouzou | ALG | 3-0 | 2-2 | Dynamos FC |  ZIM | --- | --- | 5-2 | | --.--,--.-- | US Mbila Nzambi |  GAB | 1-1 | 0-3 | Al-Ahly | EGY | --- | --- | 1-4 | | --.--,--.-- | AS Kaloum Star | GUI | 2-1 | 2-1 | ASEC Mimosas |  IVC | --- | --- | 4-2 | | --.--,--.-- | AS Vita Club | ZAI | 4-1 | 0-2 | Nchanga Rangers |  ZAM | --- | --- | 4-3 |
| dates | team 1 | leg 1 | leg 2 | team 2 | HT1 | HT2 | aggr. | | --.--,--.-- | Horseed FC |  SOM | 1-2 | 0-2 | JE Tizi-Ouzou | ALG | --- | --- | 1-4 | | --.--,--.-- | Shooting Stars FC |  NGR | 1-2 | 0-3 | Dynamos FC | ZIM | --- | --- | 1-5 | | --.--,--.-- | Nile Breweries FC |  UGA | 2-0 | 0-5 | Al-Ahly | EGY | --- | --- | 2-5 | | --.--,--.-- | US Mbila Nzambi | GAB | 2-0 | 0-1 | OC Agaza |  TOG | --- | --- | 2-1 | | --.--,--.-- | Canon Yaoundé |  CMR | 0-0 | 1-3 | ASEC Mimosas | IVC | --- | --- | 1-3 | | --.--,--.-- | Asante Kotoko |  GHA | 1-0 | 1-3 | AS Kaloum Star | GUI | --- | --- | 2-4 | | --.--,--.-- | Costa do Sol |  MOZ | 1-3 | 1-3 | Nchanga Rangers | ZAM | --- | --- | 2-6 | | --.--,--.-- | Silures |  UPV | 0-1 | 3-3 | AS Vita Club | ZAI | --- | --- | 3-4 |
| dates | team 1 | leg 1 | leg 2 | team 2 | HT1 | HT2 | aggr. | | --.--,--.-- | Al-Ahly (Tripoli) |  LBA | 0-0 | 1-2 | JE Tizi-Ouzou | ALG | --- | --- | 1-2 | | --.--,--.-- | Horseed FC | SOM | wo | wo | Simba SC |  TAN | --- | --- | w/o | | --.--,--.-- | Dynamos FC | ZIM | 5-0 | 1-1 | Linare FC |  LES | --- | --- | 6-1 | | --.--,--.-- | Shooting Stars FC | NGR | 7-1 | 0-2 | Township Rollers |  BOT | --- | --- | 7-3 | | --.--,--.-- | Al-Ahly | EGY | 3-1 | 1-1 | Abaluhya |  KEN | --- | --- | 4-2 | | --.--,--.-- | Nile Breweries FC | UGA | 2-1 | 2-0 | TP USCA Bangui |  CAR | --- | --- | 4-1 | | --.--,--.-- | US Mbila Nzambi | GAB | 1-0 | 0-1 | Real Bamako |  MLI | --- | --- | 1-1 (4-2 p) | | --.--,--.-- | OC Agaza | TOG | wo | wo | Benfica de Bissau |  GBU | --- | --- | w/o | | | Canon Yaoundé | CMR | bye as Winners of CAF Champions Cup 1980. | | --.--,--.-- | SEIB Diourbel |  SEN | 2-1 | 1-2 | ASEC Mimosas | IVC | --- | --- | 3-3 (3-4 p) | | --.--,--.-- | AS Kaloum Star | GUI | 2-1 | 1-0 | Starlight Banjul |  GAM | --- | --- | 3-1 | | --.--,--.-- | Asante Kotoko | GHA | 3-0 | 1-1 | Invincible Eleven |  LBR | --- | --- | 4-1 | | --.--,--.-- | MMM Tamatave |  MAD | 2-4 | 0-2 | Costa do Sol | MOZ | --- | --- | 2-6 | | --.--,--.-- | Nchanga Rangers | ZAM | 1-0 | 4-0 | Mbabane Highlanders |  SWA | --- | --- | 5-0 | | --.--,--.-- | East End Lions |  SLE | 1-1 | 0-1 | Silures | UPV | --- | --- | 1-2 | | --.--,--.-- | Primeiro de Agosto |  ANG | 1-1 | 2-3 | AS Vita Club | ZAI | --- | --- | 3-5 |
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