| Final 19:25 | | time | gap | L | Y | pts | 100m Bf | 200m Ba | 300m Br | | 1. Summer McIntosh |  Canada | 4:32.04 | WJ | 4 | 15 | 938 | 59.94s | 2:07.97 | 3:29.85 | | 2. Katie Grimes |  United States | 4:32.67 | +0.63s | 5 | 16 | 932 | 1:00.22 | 2:09.30 | 3:31.78 | | 3. Emma Weyant | United States | 4:36.00 | +3.96s | 3 | 20 | 898 | 1:03.57 | 2:14.37 | 3:33.33 | | 4. Katinka Hosszu |  Hungary | 4:37.89 | +5.85s | 2 | 33 | 880 | 1:02.89 | 2:13.20 | 3:34.05 | | 5. Yui Ohashi |  Japan | 4:37.99 | +5.95s | 7 | 26 | 879 | 1:02.27 | 2:13.06 | 3:33.35 | | 6. Chutong Ge |  China | 4:38.37 | +6.33s | 6 | 18 | 876 | 1:01.47 | 2:12.67 | 3:34.56 | | 7. Jenna Forrester |  Australia | 4:42.39 | +10.35s | 1 | 19 | 839 | 1:04.15 | 2:15.56 | 3:36.44 | | 8. Ageha Tanigawa | Japan | 4:44.28 | +12.24s | 8 | 19 | 822 | 1:03.30 | 2:16.37 | 3:39.27 |
| World and Championship Record: Katinka Hosszu, Hungary 4:26.36 Rio de Janeiro, Brazil 6th August 2016 |
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Heats - Saturday, 25th June 09:01 | | Best 8 times advanced to Final. |
| Heat 3 09:14 | | time | gap | L | Y | pts | Rk | 100m Bf | 200m Ba | 300m Br | | 1. Katinka Hosszu | Hungary | 4:39.15 | +3.00s | 5 | 33 | 868 | 5. | 1:03.33 | 2:13.88 | 3:34.16 | | 2. Yui Ohashi | Japan | 4:39.52 | +3.37s | 4 | 26 | 865 | 6. | 1:03.61 | 2:14.45 | 3:34.07 | | 3. Ageha Tanigawa | Japan | 4:40.70 | +4.55s | 6 | 19 | 854 | 8. | 1:02.78 | 2:14.75 | 3:36.21 | | 4. Viktoria Mihalyvari-Farkas | Hungary | 4:41.16 | +5.01s | 3 | 18 | 850 | 9. | 1:03.80 | 2:15.09 | 3:36.69 | | 5. Tessa Cieplucha | Canada | 4:44.53 | +8.38s | 2 | 23 | 820 | 11. | 1:03.94 | 2:18.05 | 3:38.96 | | 6. Freya Constance Colbert |  Great Britain | 4:45.55 | +9.40s | 7 | 18 | 811 | 12. | 1:05.42 | 2:17.22 | 3:39.83 | | 7. Cyrielle Duhamel |  France | 4:52.24 | +16.09s | 8 | 22 | 757 | 13. | 1:04.65 | 2:19.74 | 3:42.44 | | 8. Kristen Elena Romano |  Puerto Rico | 4:56.39 | +20.24s | 9 | 22 | 725 | 16. | 1:05.27 | 2:22.03 | 3:47.66 | | -. Chloe Cheng |  Hong Kong | DNS | | 0 | 17 | - | -. | -. | -. | | -. Anastasia Gorbenko |  Israel | DNS | | 1 | 18 | - | -. | -. | -. |
| Heat 2 09:08 | | time | gap | L | Y | pts | Rk | 100m Bf | 200m Ba | 300m Br | | 1. Summer McIntosh | Canada | 4:36.15 | | 5 | 15 | 897 | 1. | 1:00.81 | 2:11.17 | 3:32.25 | | 2. Katie Grimes | United States | 4:36.68 | +0.53s | 3 | 16 | 892 | 2. | 1:01.43 | 2:11.40 | 3:34.81 | | 3. Emma Weyant | United States | 4:38.52 | +2.37s | 4 | 20 | 874 | 3. | 1:04.74 | 2:15.98 | 3:35.12 | | 4. Chutong Ge | China | 4:38.95 | +2.80s | 2 | 18 | 870 | 4. | 1:02.51 | 2:13.34 | 3:35.29 | | 5. Jenna Forrester | Australia | 4:40.20 | +4.05s | 6 | 19 | 859 | 7. | 1:04.65 | 2:14.84 | 3:35.42 | | 6. Mya Rasmussen |  New Zealand | 4:41.98 | +5.83s | 7 | 22 | 842 | 10. | 1:04.62 | 2:16.83 | 3:36.50 | | 7. Gabrielle Roncatto |  Brazil | 4:52.61 | +16.46s | 1 | 23 | 754 | 14. | 1:05.45 | 2:20.06 | 3:45.24 | | 8. Florencia Perotti |  Argentina | 4:55.43 | +19.28s | 8 | 29 | 732 | 15. | 1:04.78 | 2:20.47 | 3:45.51 | | -. Nikoleta Trnikova |  Slovakia | DNS | | 0 | 19 | - | -. | -. | -. |
| Heat 1 09:01 | | time | gap | L | Y | pts | Rk | 100m Bf | 200m Ba | 300m Br | | 1. Kamonchanok Kwanmuang |  Thailand | 4:56.59 | +20.44s | 4 | 17 | 724 | 17. | 1:06.79 | 2:25.17 | 3:48.52 | | 2. Simone Kabbara |  Lebanon | 5:07.33 | +31.18s | 3 | 16 | 651 | 18. | 1:08.76 | 2:26.96 | 3:54.05 | | 3. Samantha Van Vuure |  Curacao | 5:34.75 | +58.60s | 5 | 20 | 503 | 19. | 1:14.42 | 2:35.34 | 4:19.16 |
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